The literature on kidney disease was recently expanded thanks to publications coauthored by College of Medicine students.
Third-year student Matthew Satariano and second-year student Shaarav Ghose coauthored an article with Rupesh Raina, M.D., associate professor of Internal Medicine. The article, titled The Pathophysiology of Inherited Renal Cystic Disease, was published in the journal Genes (Basel).
According to the article, renal cystic diseases (RCDs) can arise from utero to early adulthood and can lead to severe complications such as chronic kidney disease, liver disease and death. The authors examined the genetic involvement and clinical outcomes of various RCDs, providing insights for diagnosis, counseling and treatment.
Second-year student Bryce Pember coauthored a systematic review of inborn errors of metabolism (IEM) publications in Kidney Medicine. The article, coauthored by Dr. Raina and colleagues from Akron Children’s Hospital and others, is titled Kidney Replacement Therapy and Mortality in Children With Inborn Errors of Metabolism: A Meta-analysis
The retrospective study considered eligible children diagnosed with an inborn error of metabolism and receiving kidney replacement therapy [KRT] treatment.
According to the authors, “There is a noticeable scarcity of clinical trials and cross-sectional studies that investigate and validate the effectiveness of newer CKRT [continuous KRT] modalities in comparison with existing treatments among patients with inborn errors of metabolism. Future developments should consider focusing on models to assess prognostic indicators for nonsurvival risk in children with inborn errors of metabolism and optimize their intervention course for long-term positive outcomes.”